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The question most of us have is Is Zofran Over the Counter medication You might be wondering why Zofran requires a prescription However, there are other nausea medications available Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiationtreatment Ondansetron may be used for purposes not listed in this medication guide Mar 17, 2025 · While Zofran is highly effective, you cannot buy it without a prescription But don’t worry—there are other options! Why Isn’t Zofran Sold Over the Counter? 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